Microsoft Outlook 2007
When you go on leave, you might want to let people in your office know that you are away when they send an email to you. This can be accomplished in Microsoft Outlook 2007 using the Out of Office Assistant.
In Outlook, click Tools…
Select Out of Office Assistant…
Select Send Out of Office auto-replies. You can also set a date and time range. Otherwise you can go back to this screen when you return and select Do not send Out of Office auto-replies.
Microsoft Outlook 2010
Of you are an user in an Exchange environment, you can easily set an Out of Office message if you’re going to be away for a few days.
In Outlook, the Microsoft Office button in the upper-left corner.
Click Info on the left side.
Click Automatic Replies (Out of Office). If this option is grayed out, you are not connected to an Exchange server and will not be able to use this feature.
Fill out the information as needed. The email server will handle the rest while you’re gone.